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It is selective for HECT-mediated over RING-mediated ubiquitination
38 μM and 1
Toxicity: It is not believed to be addictive but it is known to produce mild withdrawal effects (e
Ichinowatari G
N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide
Yohimbine Size:2mg solid It is selective for HECT-mediatedYohimbine is a potent and relatively nonselective alpha 2 adrenergic receptor (AR) antagonist, with IC50 of 0. 6 M. IC50 value: 0. 6 uM Target: alpha 2 adrenergic receptor in vitro: Yohimbine inhibits alpha2 receptor antagonist with Ki of 1. 05 nM, 1. 19 nM, and 1. 19 nM for 2A, 2B, 2C, respectively. Yohimbine also inhibits 5 HT1B with Ki of 19. 9 nM. Yohimbine acts to block the lowering of cAMP by alpha 2 adrenoceptor agonists. yohimbine actually
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