RAF265 enafil dihydrochloride a potent and selective CRTh2

a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases

PF 4800567 is a novel and potent inhibitor of casein kinase 1 epsilon (IC50=32 nM) with greater than 20-fold selectivity over casein kinase 1 delta(IC50=711 nM)

InChiKey: IHIUGIVXARLYHP-UXNJHFGPSA-N

Chemical Name: 3-((6-(4

Studies have indicated that selective ERβ agonists like prinaberel could be useful in the clinical treatment of a variety of medical conditions including inflammatory bowel disease

RAF265 enafil dihydrochloride a potent and selective CRTh2CHIR 265 is an orally bioavailable small molecule with potential antineoplastic activity. CHIR 265 binds and inhibits Raf kinases, which may result in a reduction of tumor cell growth and proliferation, and tumor cell death. In addition, this agent inhibits vascular endothelial growth factor receptor type 2 (VEGFR 2), thereby disrupting tumor angiogenesis. Raf kinases are critical enzymes in the Ras Raf MEK ERK signaling pathway and are frequently