Y-320 - IL-17 Immunomodulator. CAS# 288250-47-5 Catalog No.:M60200-2S GJ072 is active in A-T

Name: Y-320 - IL-17 Immunomodulator. CAS# 288250-47-5 Catalog No.:M60200-2S GJ072 is active in A-T
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GJ072 is active in A-T cells with a homozygous TAA mutation

Y-320 - IL-17 Immunomodulator. CAS# 288250-47-5 Catalog No.:M60200-2S GJ072 is active in A-TY 320, CAS No. 288250 47 5, is an orally active potent immunomodulator. Y 320 inhibits IL 15 induced IL 17 production by CD4 T cells with an IC50 of 20 nM. Therapeutic treatment with Y 320 (0. 3 to 3 mg kg orally) significantly inhibited the progression of arthritis and joint destruction in type II collagen induced arthritis (CIA) in DBA 1J mice. Y 320 inhibited the elevation of IL 17 mRNA expression in the joint of CIA mice. Concomitant treatment

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