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InChi: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11
CAS Number: 150399-21-6
InChi: InChI=1S/C27H44O6/c1-15(20(28)8-9-24(2
Solubility: DMSO : ≥ 60 mg/mL (138
Dickinson BC
AZD 5153 Catalog No.:M22444-C InChi: InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11Target: BRD4 IC50: 5 nM AZD5153 is a potent, selective, and orally available inhibitor of the bromodomain and extraterminal (BET) protein BRD4, with the IC50 value of 5 nM. AZD5153 could simultaneously ligate two bromodomains in BRD4, and exert antitumor activity in multiple xenograft tumor models . In Vitro: A quantitative immuno fluorescent assay in U2OS cells revealed that AZD5153 could significantly disrupt BRD4 foci, with the IC50 value of 1. 7
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