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also known as PROTAC cIAP1 degrader-4
((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone
and suppressed tumor growth in vivo with a concomitant reduction in vessel formation
which blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma
FPS-ZM1 inhibits RAGE-mediated influx of circulating Aβ40 and Aβ42 into the brain
Exatecan Mesylate - CAS# 169869-90-3 0271 also known as PROTAC cIAP1Exatecan Mesylate, CAS No. 169869 90 3, also known as DX 8951, is semisynthetic, water soluble camptothecin derivative with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater
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